Although Southport are pretty much
in freefall, it's always tough playing against higher league opposition in a cup competition. But Boston have a good record against Southport having knocked them out of the FA Cup on two previous occasions - both 2-0 wins at Southport (
21/11/1970 and
11/10/2008). So I'm going with history - after all they do say things come in threes so my prediction is:
Southport 0-2 Boston United (725)
